Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:69682 Drake TA, et al., Genetic loci determining bone density in mice with diet-induced atherosclerosis. Physiol Genomics. 2001 Apr 27;5(4):205-15
• ID
  MGI:2151129

Genes

Gene	Assay Type
Bdt3	visible phenotype
D6Mit198

Notes

• Experiment
  Genome scan at an average marker spacing of 13 cM was performed on female animals from a (C57BL/6J x DBA/2J)F2 intercross to identify QTLs associated with bone density and bone density related traits. Animals were placed on a 16 week atherogenic diet at 12 months of age. QTLs were identified on mouse Chromosome 2 spanning 90 cM - 130 cM (Bdt1, LOD = 5.65 at D2Mit413), mouse Chromosome 3 spanning 40 cM - 70 cM (Bdt2, LOD = 8.09 at D3Mit14), mouse Chromosome 6 spanning 60 cM - 85 cM (Bdt3, LOD = 6.4 at D6Mit198), mouse Chromosome 7 spanning 0 cM - 50 cM (Bdt4, LOD = 8.28 at D7Mit80), and mouse Chromosome 15 spanning 0 cM - 30 cM (Bdt5, LOD = 6.13 at D15Mit13) and spanning 20 cM - 50 cM (Bdt6, LOD = 7.73 at D15Mit206). ANOVA analysis detected interaction between Bdt3 on Chromosome 6 and Bdt5 on Chromosome 15. Bdt1, Bdt2, and Bdt3 colocalize with QTLs for nonbone traits and may indicate pleiotropic effects at these loci. Further investigation concluded Bdt2 is distinct from colocalizing loci for body length and HDL cholesterol, but did not rule out pleiotropy at Bdt1 for adipose mass and HDL cholesterol and at Bdt2 for plasma HDL and subcutaneous fat pad mass.