Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:69352 Pereira RA, et al., Cutting edge: a NK complex-linked locus governs acute versus latent herpes simplex virus infection of neurons. J Immunol. 2001 May 15;166(10):5869-73
• ID
  MGI:2151138

Genes

Gene	Assay Type
Rhs1	resistance/susceptibility
D6Mit108
Klrb1a	reported elsewhere
Tnfrsf1a	reported elsewhere
D6Mit52
D6Mit194

Notes

• Experiment
  A locus conferring resistance to herpes simplex virus infection, Rhs1, mapped to 48.1 cM - 62.1 cM on mouse Chromosome 6 using congenic strain BALB.B6.Cmv1^s and a series of C57BL/6- and BALB/c-derived intra-NKC recombinant lines. Progenitor strain BALB/c is susceptible to infection with herpes simplex virus whereas progenitor strain C57BL/6 (B6) is resistant to infection. Congenic strain BALB.B6.Cmv1^s carries C57BL/6-derived chromosome 6 DNA spanning 60.55 cM - 65 cM on a BALB/c genetic background, and retains the herpes simplex resistant phenotype of donor strain C57BL/6. Intra-NKC recombinant lines carrying subportions of C57BL/6-derived congenic region on a BALB/c background were used to localize Rhs1 to the proximal portion of the interval.