Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  18
• Reference
  J:67467 Zhang Z, et al., Fine mapping and characterization of candidate lung tumor resistance genes for the Par2 locus on mouse chromosome 18. Exp Lung Res. 2000 Dec;26(8):627-39
• ID
  MGI:2151348

Genes

Gene	Assay Type
Par2	resistance/susceptibility
D18Mit103
D18Mit162
Smad4	reported elsewhere
Smad2	reported elsewhere
Dcc	reported elsewhere
D18Mit34
D18Mit4
D18Mit119
D18Mit202
D18Mit36
D18Mit122
D18Mit207

Notes

• Experiment
  Study of 81 recombinant congenic strains localized the Par2 locus to a 6 cM interval on mouse Chromosome 18 spanning 44 cM - 50 cM flanked by D18Mit103 and D18Mit162. Congenic strains were constructed by backcrossing susceptible donor strain A/J to resistant recipient strain BALB/c for 9 generations, selecting for the Par2 region and recombination events across the Par2 region at each generation. Parental strain A/J develops more lung tumors when induced with urethane compared to BALB/c. Susceptibility to pulmonary adenoma after treatment with urethane was observed in congenic animals retaining A/J-derived DNA across D18Mit103 and D18Mit162. Possible candidate genes in the Par2 interval include Smad4, Smad2, and Dcc.