Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  16
• Reference
  J:69212 Mori N, et al., A susceptibility locus for radiation lymphomagenesis on mouse chromosome 16. J Radiat Res (Tokyo). 2000 Dec;41(4):367-72
• ID
  MGI:2151359

Genes

Gene	Assay Type
Ritls	resistance/susceptibility
D16Mit34
D16Mit165

Notes

• Experiment
  Ritls, a locus associated with radiation induced thymic lymphoma susceptibility was mapped to an interval on mouse chromosome 16 spanning 9.61 cM-10.3 cM using a (Ccs-7/Dem x BALB/c)F1 x BALB/c backcross. Recombinant congenic strain Ccs-7/Dem derives 12.5% of its genome from inbred strain STS/A on a BALB/c background and is resistant to radiation induced lymphogenesis. Parental inbred strain BALB/c is susceptible to radiation induced lymphogenesis whereas parental inbred strain STS/A is resistant. Female backcross animals 4-5 weeks of age were exposed to X-irradiation and observed for lymphomagenesis. D16Mit34, a marker at centromeric mouse chromosome 16 is associated with susceptibility to thymic lymphomas in animals homozygous for STS/A- or BALB/c-derived alleles (90% and 91% incidence of thymic lymphoma, respectively). Animals heterozygous at D16Mit34 appear to be more resistant (69% incidence of thymic lymphoma).