Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:71471 Fortin A, et al., Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10793-8
• ID
  MGI:2151487

Genes

Gene	Assay Type
Char4	resistance/susceptibility
D3Mit109
D3Mit14
D3Mit349
D3Mit351

Notes

• Experiment
  199 animals from a (AcB55/Mcg x A/J)F2 intercross were used to map QTLs associated with malaria resistance. AcB55/Mcg is a highly resistant recombinant congenic strain derived from progenitor strains A/J (susceptible) and C57BL/6J (resistant). AcB55/Mcg is homozygous for malaria susceptibility alleles at Char1 (on mouse Chromosome 9) and Char2 (on mouse Chromosome 8) to maximize identification of novel malaria resistance loci in the current screen. Male and female animals 8-12 weeks of age were infected with Plasmodium chabaudi and assessed for parasitemia. Significant linkage was detected on mouse Chromosome 3 near D3Mit109 (LOD = 6.57 at approximately 61.8 cM) and the locus was named Char4 (P. chabaudi malaria resistance QTL 4). Resistance to malaria appears to be recessively inherited at Char4 and there is evidence of additive interactions with a codominantly or dominantly inherited locus on mouse Chromosome 10 (LOD = 2.53 near D10Mit189).