Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  4
• Reference
  J:71358 Saito Y, et al., Genetic loci controlling susceptibility to gamma-ray-induced thymic lymphoma. Oncogene. 2001 Aug 23;20(37):5243-7
• ID
  MGI:2151622

Genes

Gene	Assay Type
Mtf1	resistance/susceptibility
D4Mit12
Txlna	reported elsewhere
Ifna	reported elsewhere
Tyrp1	reported elsewhere
D4Mit331
D4Mit278

Notes

• Experiment
  67 polymorphic markers at an average spacing of 24 cM were typed in 220 (BALB/c x MSM)F1 x MSM backcross animals to identify QTLs involved in susceptibility to gamma-irradiation induced thymic lymphomas. Parental strain BALB/c is susceptible to gamma-irradiation induced thymic lymphomas whereas parental strain MSM is resistant. (BALB/c x MSM)F1 hybrid animals are susceptible to gamma-irradiation induced thymic lymphomas. Thyls (thymic lymphoma susceptibility) was identified on mouse chromosome 4 near D4Mit12 (P = 0.0037) in the backcross and confirmed using partially congenic animals carrying MSM-derived DNA in the region of D4Mit12 on a BALB/c background. BALB/c-derived alleles confer dominantly inherited susceptibility to gamma-irradiation induced thymiclymphomas at Thyls. Possible candidate genes in the region of Thyls are Il14, Ifna, and Tyrp1. Suggestive linkages for gamma-irradiation induced thymic lymphoma susceptibility were detected on mouse Chromosome 2 near D2Mit15 and mouse Chromosome 5 near D5Mit5.