Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:70961 Mehrabian M, et al., Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ Res. 2001 Jul 20;89(2):125-30
• ID
  MGI:2151625

Genes

Gene	Assay Type
Artles	resistance/susceptibility
D6Mit256
Pparg	reported elsewhere
D6Mit102
D6Mit105
Apobec1	reported elsewhere
D6Mit111
D6Mit14
D6Mit198

Notes

• Experiment
  Genome scan at an average marker density of 10 cM was performed on approximately 250 (CAST/Ei x C57BL/6J)F2 animals to identify QTLs associated with arterial lesion formation. Animals were places on a 15 week atherogenic diet at 4 months of age. Parental strain CAST/Ei is resistant to atherosclerosis when placed on an atherogenic diet whereas parental strain C57BL/6J is susceptible. A significant QTL associated with arterial lesion formation and insulin level, Artles, mapped to approximately 61 cM on mouse Chromosome 6 with a maximum LOD score 6.7 near D6Mit256. Artles spans an interval of 38.5 cM - 67 cM and appears to be inherited in a codominant fashion. Artles was confirmed in congenic strains carrying CAST/Ei-derived DNA spanning 38.5 cM - 67 cM ofmouse Chromosome 6 (D6Mit102 to D6Mit198) on a C57BL/6J background. The congenics exhibited similar resistance to arterial lesions as donor strain CAST/Ei. The same protective effect was observed in a congenic strain carrying the same CAST/Ei-derived region (38.5 cM-67 cM of mouse Chromosome 6) on a highly susceptible LDLR -/- background. Possible candidate genes in the region of Artles include Pparg and Apobec1.