Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:70882 Ji H, et al., Genetic influences on the end-stage effector phase of arthritis. J Exp Med. 2001 Aug 6;194(3):321-30
• ID
  MGI:2151752

Genes

Gene	Assay Type
Stia1	resistance/susceptibility
D1Mit33
D1Mit36
Fcgr2b	reported elsewhere
Sele	reported elsewhere
Sell	reported elsewhere
Selp	reported elsewhere
Fasl	reported elsewhere
D1Mit396
Ncf2	reported elsewhere
Cfh	reported elsewhere
Il10	reported elsewhere
Pigr	reported elsewhere
C4bp	reported elsewhere
Cd55	reported elsewhere
Cxcr4	reported elsewhere
D1Mit102

Notes

• Experiment
  132 animals from a (C57BL/6J x NOD/LtDOI)F2 intercross were typed for 162 microsatellite markers at an average spacing of 7.84 cM to identify QTLs associated with susceptibility to rheumatoid arthritis. (C57BL/6J x NOD/LtDOI)F2 animals were inoculated with serum from K/BXN T cell receptor transgenic mice to induce arthritis. Parental strain C57BL/6J is susceptible to serum transfer induced arthritis whereas NOD/LtDOI is resistant. Stia1 (serum transfer induced arthritis 1) maps to 81.6 cM on mouse Chromosome 1 with a LOD score of 4.5 at D1Mit33. The Stia1 interval spans 79 cM - 92. cM. Stia2 maps to 23.5 cM on mouse Chromosome 2 with a LOD score of 7 at the Hc (hemolytic complement) locus. The Stia2 locus spans 11 cM - 41.4 cM. Hc is a possible candidategene for Stia2 because Hc appears to be required to develop arthritis via serum transfer, and Hc is known to be defective in the NOD/LtDOI strain.