Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:71668 Hardy CL, et al., Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine gamma-herpesvirus-induced infectious mononucleosis. Immunogenetics. 2001 Jul;53(5):395-400
• ID
  MGI:2151776

Genes

Gene	Assay Type
Trbv4c1	visible phenotype
D17Mit136
Tcte1	reported elsewhere
D17Mit135
D17Ncvs41

Notes

• Experiment
  Linkage analysis was performed on a (C57BL/6J x DBA/2J)F1 x C57BL/6J backcross and 25 BXD (B = C57BL/6J, D = DBA/2J) recombinant inbred (RI) strains to identify QTLs associated with TRBV4 CD8+ T cell proliferation during infection with murine gamma-herpes virus. Parental strain DBA/2J is a low responder yielding a low level of TRBV4 proliferation whereas parental strain C57BL/6J is a high responder. Trbv4c1 and Trbv4c2 were identified in the backcross and RI strains an map to mouse Chromosome 17 at 23 cM (LRS = 17.7 at D17Mit136) and mouse Chromosome 6 at 0.5 cM (LRS = 12.2 at D6Mit86), respectively. Trbv41c is located in an interval overlapping the H2 locus and spans 12 cM - 26 cM on mouse Chromosome 17, mapping near Tcte1. Trbv4c2 is located in an interval containing Tcrb and Cd8a and spans approximately 0 - 30 cM on mouse Chromosome 6.