Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:71216 Thach DC, et al., Genetic control of neuroadapted sindbis virus replication in female mice maps to chromosome 2 and associates with paralysis and mortality. J Virol. 2001 Sep;75(18):8674-80
• ID
  MGI:2151876

Genes

Gene	Assay Type
Nsv1	visible phenotype
D2Mit447
D2Mit63
D2Mit30
D2Mit104
D2Mit164
Fkbp7	reported elsewhere
Fshb	reported elsewhere
Kcna4	reported elsewhere
Snap23	reported elsewhere
Blvra	reported elsewhere
Chrm5	reported elsewhere
Cat	reported elsewhere
Rag1	reported elsewhere
Rag2	reported elsewhere
Bdnf	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on CXB (C = BALB/cBy, B = C57BL/6J) recombinant inbred (RI) strains to identify loci associated with susceptibility to Neuroadapted Sindbis virus (NSV) infection. Progenitor strain BALB/cBy is resistant to infection by NSV whereas progenitor strain exhibits C57BL/6J 100% mortality from encephalomyelitis post-infection. A suggestive QTL linked to NSV viral RNA levels was detected on mouse Chromosome 2 from 65.2 cM - 71 cM and mapped in a (C57BL/6J x BALB/cBy)F2 intercross as highly significant (LRS = 16 at D2Mit447). C57BL/6J-derived alleles contribute to increased viral RNA levels in female animals at this locus, designated Nsv1. Nsv1 maps near Fkbp7, Fshb, Kcna4, Snap23, Blvra, Chrm5, Cat, Rag1, Rag2, and Bdnf. Bdnf is being investigated as a possible candidate gene for Nsv1. A suggestive locus mapped to mouse Chromosome 7 near D7Mit223 but was not able to be confirmed in the F2 intercross.