TEXT Mapping MGI Mouse MGI:2152751

Mapping Data

Experiment

TEXT
Chromosome

6
Reference

J:70825 Kohlhepp RL, et al., The ROSA26 LacZ-neoR insertion confers resistance to mammary tumors in ApcMin/+ mice. Mamm Genome. 2001 Aug;12(8):606-11
ID

MGI:2152751

Experiment

The Gt(ROSA)26Sor insertion on mouse chromosome 6 confers resistance to ENU induced mammary tumors in female C57BL/6J-Apc^min/+ animals. Gt(ROSA)26Sor maps between D6Mit105 and D6Mit11 and was generated on a 129X1/SvJ genetic background. Female animals from recombinant congenic lines containing Gt(ROSA)26Sor on a C57BL/6J-Apc^min/+ background are resistant to mammary tumors following ENU treatment while female animals from congenic lines containing 129X1/SvJ-derived DNA from D6Mit36-D6Mit150 on a C57BL/6J-Apc^min/+ background are susceptible. Authors suggest mammary tumor resistance is not due to a 129X1/SvJ-derived passenger gene that modifies the mammary tumor promoting effect of Apc^min, but is the direct effect of the Gt(ROSA)26Sor insertion on mouse chromosome 6.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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