Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  6
• Reference
  J:70825 Kohlhepp RL, et al., The ROSA26 LacZ-neoR insertion confers resistance to mammary tumors in ApcMin/+ mice. Mamm Genome. 2001 Aug;12(8):606-11
• ID
  MGI:2152751

Genes

Gene	Assay Type
Gt(ROSA)26Sor	resistance/susceptibility
D6Mit105
D6Mit11
D6Mit36
D6Mit55
D6Mit150

Notes

• Experiment
  The Gt(ROSA)26Sor insertion on mouse chromosome 6 confers resistance to ENU induced mammary tumors in female C57BL/6J-Apc^min/+ animals. Gt(ROSA)26Sor maps between D6Mit105 and D6Mit11 and was generated on a 129X1/SvJ genetic background. Female animals from recombinant congenic lines containing Gt(ROSA)26Sor on a C57BL/6J-Apc^min/+ background are resistant to mammary tumors following ENU treatment while female animals from congenic lines containing 129X1/SvJ-derived DNA from D6Mit36-D6Mit150 on a C57BL/6J-Apc^min/+ background are susceptible. Authors suggest mammary tumor resistance is not due to a 129X1/SvJ-derived passenger gene that modifies the mammary tumor promoting effect of Apc^min, but is the direct effect of the Gt(ROSA)26Sor insertion on mouse chromosome 6.