Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  3
• Reference
  J:63571 Haddad R, et al., Restriction landmark genomic scanning of mouse liver tumors for gene amplification: overexpression of cyclin A2. Biochem Biophys Res Commun. 2000 Jul 21;274(1):188-96
• ID
  MGI:2152912

Genes

Gene	Assay Type
Ccna2	reported elsewhere
Fgf2	reported elsewhere
D3Rik65
D3Rik66
Anxa5	reported elsewhere
Mecom	reported elsewhere
Idd3	reported elsewhere
Il2	reported elsewhere

Notes

• Experiment
  Restriction Landmark Genomic Scanning (RLGS) was performed on liver tumor samples from MTD2BL/6 animals. A region on mouse chromosome 3 near D3Rik65 and D3Rik66 (approximately 19.2 cM) was found to be associated with liver tumors and included candidate oncogenes Anxa5, Evi1, Idd3, Il2, Ccna2, and Fgfr. Further analysis of this region excluded Evi1, Il2, Fgf2, and Anxa5 os possible candidate genes. Expression of Ccna2 mRNA and protein was shown to be upregulated in liver tumors, indicating the possible role of Ccna2 in liver tumorigenesis.