Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  7
• Reference
  J:65010 Saran A, et al., Genetics of chemical carcinogenesis: analysis of bidirectional selective breeding inducing maximal resistance or maximal susceptibility to 2-stage skin tumorigenesis in the mouse. Int J Cancer. 2000 Nov 1;88(3):424-31
• ID
  MGI:2152935

Genes

Gene	Assay Type	Description
Tyr	reported elsewhere
Skts2	visible phenotype	yes

Notes

• Experiment
  Segregation analysis of a (Car-R x Car-S)F2 intercross revealed association of coat color with skin tumor susceptibility. Phenotypically selected inbred lines Car-R and Car-S are derived from progenitor strains A/J, DBA/2J, P/J, CBA/J, SJL/J, BALB/cJ, SWR/J, and C57BR/6J. Animals resistant or susceptible to skin tumors after challenge with carcinogens were selected as progenitors for each successive generation in the Car-R and Car-S lines, respectively. By the eighth generation of inbreeding all Car-S mice had white coats and all Car-R mice had coats of various colors. Authors estimate 7-10 QTLs affect skin tumor susceptibility. A region on mouse chromosome 7 containing the albino locus, Tyr, and a skin tumor susceptibility QTL, Skts2, may be a candidatelocus.