Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:44580 Woo DD, et al., Genetic identification of two major modifier loci of polycystic kidney disease progression in pcy mice. J Clin Invest. 1997 Oct 15;100(8):1934-40
• ID
  MGI:2153735

Genes

Gene	Assay Type
Mopkd1	visible phenotype
D4Mit111
D4Mit194
D4Mit245
D4Mit44
D4Mit79

Notes

• Experiment
  Genome scan was performed on 114 (DBA/2 x CAST/Ei)F2-pcy/pcy animals using 150 microsatellite markers at an average spacing of 10 cM to identify QTLs affecting progression of polycystic kidney disease (PKD). (DBA/2-pcy/pcy was crossed to CAST/Ei to generate pcy/pcy F2 animals.) Animals were phenotyped at 6 weeks of age for left kidney/body weight ratios. The pcy recessive mutation on mouse Chromosome 9 results in PKD by 8 weeks of age and death by 25 weeks of age (in the homozygous state) on a DBA/2 background. Interacting loci affecting PKD progression were identified on mouse Chromosome 4 (Mopkd1) and mouse Chromosome 16 (Mopkd2). Mopkd1 spans 12.1 cM - 42.5 cM on mouse Chromosome 4 with a peak LOD score of 10.3 at D4Mit111. Mopkd2 spans 9.7 cM - 28.5 cM on mouse Chromosome 16 with a LOD score of 13.8 at D16Mit1. DBA/2-derived alleles and CAST-derived alleles at Mopkd1 and Mopkd2 interact in an additive fashion to influence PKD progression in (DBA/2 x CAST/Ei)F2-pcy/pcy animals.