Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:11381 Rise ML, et al., Genes for epilepsy mapped in the mouse. Science. 1991 Aug 9;253(5020):669-73
• ID
  MGI:2155263

Genes

Gene	Assay Type
Myo5a	reported elsewhere
Bmp5	reported elsewhere
El1	resistance/susceptibility
Mpmv27	reported elsewhere
Glb1	reported elsewhere
El7	resistance/susceptibility

Notes

• Experiment
  (DBA/2J x EL)F1 x DBA/2J and (ABP/LeJ x EL)F1 x ABP/LeJ backcross populations were used to map QTLs associated with susceptibility to epileptic seizures. Parental strain EL is highly susceptible to epileptic seizures whereas parental strains DBA/2J and ABP/LeJ are resistant. F1 hybrid animals exhibit seizure susceptibility to a lesser degree than parental strain EL.
  
  A locus with significant association to epileptic seizures, El1, was detected on mouse Chromosome 9 (P<0.001) in both backcross populations. El1 maps near Mpmv27, Myo5a, Bmp5, and Glb1 and gives a peak LOD score of 5.88 between Glb1 and Bmp5.
  
  7.13.2015 Curator Note: Because two different crosses were used in this study we consider each QTL to be unique. We have left the QTL identified here, using the (DBA/2J x EL)F1 x DBA/2J backcross, with the original El1 nomenclature. We have named the QTL identified using the (ABP/LeJ x EL)F1 x ABP/LeJ backcross as El7.
  
  A locus significantly linked to seizures, El2, was detected on mouse Chromosome 2(P<0.001) in the (ABP/LeJ x EL)F1 x ABP/LeJ backcross population. El2 is linked to Mpmv28 with a peak LOD score of 5.2.