Mapping Data

Experiment

• Experiment
  TEXT-Meta Analysis
• Chromosome
  3
• Reference
  J:72842 Belknap JK, et al., The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies. Mamm Genome. 2001 Dec;12(12):893-9
• ID
  MGI:2155433

Genes

Gene	Assay Type
Letohc1	reported elsewhere
Alcp3	reported elsewhere

Notes

• Experiment
  Authors performed meta-analysis for alcohol preference QTLs reported across several studies using C57BL/6J and DBA/2J inbred strains. C57BL/6J exhibits strong preference for alcohol whereas DBA/2J exhibits strong avoidance of alcohol. Several regions of the mouse genome are consistently associated with the alcohol preference phenotype. Alcp1, Ap2q, Etohc1, and Etohc2 map to the proximal to mid region of mouse Chromosome 2. There is evidence of dominance effects of DBA/2J-derived alleles in this region. Ap5q and Etohc3 map to the proximal to mid region of mouse Chromosome 9 and the C57BL/6J-derived allele exhibits dominance at these loci. Ap3q maps to distal mouse Chromosome 4 with C57BL/6J-derived alleles exhibiting dominance, and Alcp3 and Letohc1 map to the mid to distal region of mouse Chromosome 3 with male-specific additive inheritance.
  
  The meta-analysis was performed using the following studies:
  
  J:40854, Belknap JK; Richards SP; O'Toole LA; Helms ML; Phillips TJ, Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in
  mice., Behav Genet 1997 Jan;27(1):55-66
  
  J:33277, Melo JA; Shendure J; Pociask K; Silver LM, Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/ 6 mice., Nat
  Genet 1996 Jun;13(2):147-53
  
  J:52086, Peirce JL; Derr R; Shendure J; Kolata T; Silver LM, A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice.,
  Mamm Genome 1998 Dec;9(12):942-8
  
  J:20482, Phillips TJ; Crabbe JC; Metten P; Belknap JK, Localization of genes affecting alcohol drinking in mice., Alcohol Clin Exp Res 1994 Aug;18(4):931-41
  
  J:52468, Phillips TJ; Belknap JK; Buck KJ; Cunningham CL, Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption., Mamm
  Genome 1998 Dec;9(12):936-41
  
  J:25698, Rodriguez LA; Plomin R; Blizard DA; Jones BC; McClearn GE, Alcohol acceptance, preference, and sensitivity in mice. II. Quantitative trait loci
  mapping analysis using BXD recombinant inbred strains., Alcohol Clin Exp Res 1995 Apr;19(2):367-73
  
  J:49707, Tarantino LM; McClearn GE; Rodriguez LA; Plomin R, Confirmation of quantitative trait loci for alcohol preference in mice., Alcohol Clin Exp Res 1998
  Aug;22(5):1099-105
  
  J:56967, Whatley VJ; Johnson TE; Erwin VG, Identification and confirmation of quantitative trait loci regulating alcohol consumption in congenic strains of mice.,
  Alcohol Clin Exp Res 1999 Jul;23(7):1262-7