Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:33858 Taylor BA, et al., Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling. Genomics. 1996 Jun 15;34(3):389-98
• ID
  MGI:2156989

Genes

Gene	Assay Type
Obq2	visible phenotype
D1Mit231
D1Mit211
D1Mit410
D1Mit294

Notes

• Experiment
  Loci affecting obesity were mapped in a (129T2/SvEmsJ x EL/Suz)F2 intercross population using QTL analysis and DNA pooling strategy. Parental strain 129T2/SvEmsJ exhibits a lean phenotype whereas parental strain EL/Suz is prone to obesity. Significant linkage to adiposity index (LOD=8.0), percent inguinal fat (LOD=6.1), percent gonadal fat (LOD=8.4), percent retroperitoneal fat (LOD=7.9), body mass index (LOD=5.1), and 16 week body weight (LOD=4.5) was detected at a locus spanning 21 cM - 49 cM on mouse Chromosome 7. This locus was named Obq1 with peak linkage near D7Mit248. EL/Suz-derived alleles confer increased adiposity in a dominant fashion at Obq1. A second locus, Obq2, was detected at 12 cM - 15 cM on mouse Chromosome 1. Obq2 is linked to adiposity index (LOD=4.0) at D1Mit231. 129T2/SvEmsJ-derived alleles confer increased adiposity in a dominant fashion at Obq2.