Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  7
• Reference
  J:33253 Ivandic BT, et al., A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5483-8
• ID
  MGI:2156991

Genes

Gene	Assay Type
Abcc6	visible phenotype
Hrc	reported elsewhere
D7Mit229

Notes

• Experiment
  Dyscalc1, a locus affecting dystrophic cardiac calcinosis (DCC), was mapped to 23 cM on mouse Chromosome 7 using genome scan on 197 female animals from a (C57BL/6J x C3H/HeJ)F2 intercross. Parental strain C57BL/6J is resistant to DCC whereas C3H/HeJ is susceptible. Dyscalc1 gave a maximum LOD score of 14.6 near D7Mit229. C3H/HeJ-derived alleles confer recessive susceptibility to DCC at this locus. Dyscalc1 was confirmed in BXH recombinant inbred strains. The Dyscalc1 locus is syntenic to human chromosomes 19q13 and 11p15.