Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• ID
  MGI:2157424

Genes

Gene	Assay Type
Etohcta8	visible phenotype
D9Mit10
Htr1b	reported elsewhere

Notes

• Experiment
  841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta8 (P<0.01 at D9Mit10) mapped to Chromosome 9 at 49 cM. Etohcta8 is associated with ethanol-induced taste aversion at low-dose ethanol injection following the paired taste. A potential candidate gene mapping near Etohcta8 is the serotonin receptor, Htr1b.