Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  1
• Reference
  J:72900 Lamhamedi-Cherradi SE, et al., Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice. Diabetes. 2001 Dec;50(12):2874-8
• ID
  MGI:2158431

Genes

Gene	Assay Type
Idd5.1	resistance/susceptibility
D1Mit279
D1Mit302
D1Mit22
D1Mit479
Cd28	reported elsewhere
D1Nds25
Ctla4	reported elsewhere
Icos	reported elsewhere
D1Mit249
D1Mit301
D1Mit303
D1Mit300
D1Mit480
D1Mit5.1
D1Mit156
D1Mit21
D1Mit178
D1Mit19

Notes

• Experiment
  Recombinant congenic strains derived from NOD and C57BL/6J parentals resolved the Idd5 locus to two separate QTLs, Idd5a and Idd5b. Idd5a was localized to a region spanning 32.8 cM - 34.8 cM on mouse Chromosome 1 bounded by the markers D1Mit302 and D1Mit178. As a result, Cflar and Casp8 were excluded as candidate genes for Idd5a. Icos, Cd28, and Ctla4 remain candidate genes for Idd5a. C57BL/6J-derived alleles confer dominant resistance to diabetes at this locus. Idd5a is syntenic to human Chromosome 2q33 and may be the orthologue of IDDM12 in humans.