Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:36714 Alexander RC, et al., Quantitative trait loci contributing to phencyclidine-induced and amphetamine-induced locomotor behavior in inbred mice. Neuropsychopharmacology. 1996 Nov;15(5):484-90
• ID
  MGI:2159386

Genes

Gene	Assay Type
Pcpila1	visible phenotype
D1Mit17
Pmv21	reported elsewhere
D1Byu9
Gstp-rs1	reported elsewhere

Notes

• Experiment
  26 BXD (B=C57BL/6J; D=DBA/2J) recombinant inbred (RI) strains were analyzed for QTLs linked to PCP- and amphetamine-induced activation of locomotor activity. Parental strain C57BL/6J exhibits greater locomotor behavior following PCP administration compared to DBA/2J. Loci affecting PCP induced locomotor activity (Pcpila) mapped to 106.3 cM on mouse Chromosome 1 (Pcpila1), 2 cM on mouse Chromosome 14 (Pcpila2), and 38.2 cM on mouse Chromosome 15 (Pcpila3). C57BL/6J-derived alleles confer increased PCP induced locomotor activity at all mapped loci.