Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:72360 Bergman ML, et al., Low rate of proliferation in immature thymocytes of the non-obese diabetic mouse maps to the Idd6 diabetes susceptibility region. Diabetologia. 2001 Aug;44(8):1054-61
• ID
  MGI:2159720

Genes

Gene	Assay Type
D6Mit14
D6Mit15
Idd6	resistance/susceptibility

Notes

• Experiment
  Female animals from a (C57BL/6 x NOD)F2 cross were screened for markers near Idd (insulin dependent diabetes) susceptibility loci to determine if any previously identified diabetes QTLs were associated with impaired thymocyte proliferation. Parental strain NOD exhibits slower thymocyte proliferation compared to C57BL/6 (thymocyte recovery in NOD is only 71% of C57BL/6). Markers on mouse Chromosome 6 near Idd6 showed linkage to this trait with a maximum LOD score of 5.36 at D6Mit15. NOD-derived alleles appear to confer dominantly inherited thymocyte proliferation impairment with reduced penetrance at Idd6.