Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:73932 Johansson AC, et al., The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross. Eur J Immunol. 2002 Jan;32(1):243-50
• ID
  MGI:2176547

Genes

Gene	Assay Type
Nss1	resistance/susceptibility
D4Mit27
D4Mit28
D4Mit9
D4Mit166
D4Mit114
D4Mit178
D4Mit17
Ifna	reported elsewhere
Ifnb1	reported elsewhere
Orm1	reported elsewhere
Orm2	reported elsewhere

Notes

• Experiment
  Genome scan was performed on 353 (NOD.Q-H2^q x B10.Q)F2 animals using 155 markers at an average density of 8.6. cM to identify QTLs associated with non-arthritis-dependent sialadenitis. Parental strain NOD.Q-H2^q is susceptible to sialadenitis whereas B10.Q is resistant. A locus on mouse Chromosome 4 named Nss1 (NOD Sjogren's syndrome 1) showed significant linkage to sialadenitis with a LOD score of 4.7 at D4Mit27 (approximately 42.5 cM). The QTL range of Nss1 spans 28.6 cM - 48.5 cM on mouse Chromosome 4. NOD-derived alleles contribute sialadenitis susceptibility in a recessively inherited fashion at this locus. Possible candidate genes in the region of Nss1 are the type 1 IFN genes Ifna and Ifnb, and the orosomucoids Orm1 and Orm2.