Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  2
• Reference
  J:73640 Phan J, et al., The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism. J Biol Chem. 2002 Jan 4;277(1):469-77
• ID
  MGI:2177265

Genes

Gene	Assay Type
Malrd1	visible phenotype
D2Mit117
D2Mit76
D2Mit79
Nr1h3	reported elsewhere
Abcb11	reported elsewhere

Notes

• Experiment
  The Diet1 locus was shown to segregate with plasma bile acid levels in a (C57BL/6By x CAST/Ei)F1 x C57BL/6By backcross. Animals homozygous for C57BL/6By-derived alleles at D2Mit117 exhibit significantly higher plasma bile acid levels than animals heterozygous at D2Mit117. In this study the Diet1 locus spans an 8 cM interval on mouse Chromosome 2 from 2 cM - 10 cM flanked by markers D2Mit76 and D2Mit79. Based on mapping data, 2 candidate genes, Nr1h3 (referred to as LXRalph) and Abcb11 (referred to as Bsep), were excluded because they mapped outside the Diet1 interval and did not segregate with the phenotype.