Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:74369 Angel JM, et al., Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4. Mol Carcinog. 2002 Feb;33(2):105-12
• ID
  MGI:2177629

Genes

Gene	Assay Type
Tlag2	resistance/susceptibility
D4Mit306
D4Mit278
D4Mit37
D4Mit124
Cdkn2a	reported elsewhere
Cdkn2b	reported elsewhere
Tie1	reported elsewhere
Tek	reported elsewhere
Jun	reported elsewhere
Mycl	reported elsewhere
Tal1	reported elsewhere

Notes

• Experiment
  Tlag2, a gene responsible for MNU-induced lymphoma susceptibility, was mapped to 53 cM on mouse Chromosome 4 in a AKR/J x (AKR/J x C57L/J)F1 backcross and confirmed in F2 and F3 animals. (Animals fixed for AKR/J-derived alleles at Tlag1 on mouse Chromosome 7 were used in the study.) Peak lymphoma susceptibility is associated with marker Pmv19 at 52.7 cM with the C57L/J-derived allele conferring dominant lymphoma susceptibility. Tlag1 and Tlag2 appear to interact. Animals homozygous for AKR-derived alleles at Tlag1 and heterozygous at Tlag2 exhibited the highest incidence of MNU-induced tumors. Several candidate genes mapping near Tlag2 are Cdkn2a, Cdkn2b, Lyr, Pcts, Tie1, Tek, Mycl1, Jun, Lck, Pctr1, Pctr2, and Tal1.