Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:75819 Shimizu M, et al., Chromosome 13 locus, Pbd2, regulates bone density in mice. J Bone Miner Res. 2001 Nov;16(11):1972-82
• ID
  MGI:2178368

Genes

Gene	Assay Type
Pbd2	visible phenotype
D13Mit174
D13Mit153
D13Mit115
D13Mit266
D13Mit60
D13Mit117
D13Mit177
D13Mit88
Inhba	reported elsewhere
Bmp6	reported elsewhere

Notes

• Experiment
  Pbd2, a QTL associated with peak bone density, was confirmed using congenic strain P6.P2-Pbd2^b. P6.P2-Pbd2^b carries a 15 cM interval of mouse Chromosome 13 derived from the high bone density SAMP2 strain on the genetic background of the osteoporotic strain SAMP6. This 15 cM congenic region encompasses markers D13Mit174, D13Mit135, D13Mit115, D13Mit266, D13Mit60, D13Mit117, D13Mit177, and D13Mit88. The congenic strain indeed exhibits increased bone density compared to the osteoporotic SAMP6 backgroundstrain, thus confirming the presence of the Pbd2 QTL. A possible candidate gene, Inhba, found at 10 cM on chromosome 13, was investigated but no difference in expression between SAMP2 and SAMP6 could be found. Another candidate gene is Bmp6, found at 20 cM on chromosome 13. Polymorphisms in Bmp6 exist between strains SAMP2 and SAMP6 and this candidate gene is being studied further.