Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:73358 Hunter KW, et al., Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1. Cancer Res. 2001 Dec 15;61(24):8866-72
• ID
  MGI:2179207

Genes

Gene	Assay Type
Mtes1	visible phenotype
Slc3a2	reported elsewhere
Brms1	reported elsewhere

Notes

• Experiment
  18 AKXD (AK = AKR/J; D = DBA/2J) recombinant inbred (RI) strains and the following backcrosses were used to map loci associated with suppression of mammary tumor metastasis: (I/LnJ x FVB/N-TgN(MMTVPyVT)634Mul)F1 x FVB/NJ, (DBA/2J x FVB/N-TgN(MMTVPyVT)634Mul)F1 x FVB/NJ, and (NZB/BINJ x FVB/N-TgN(MMTVPyVT)634Mul)F1 x FVB/NJ. Significant linkage to mammary tumor metastasis mapped to proximal mouse Chromosome 19 near Slc3a2 (LOD = 3.6) at approximately 4 cM in the AKXD RI strains, and was named Mtes1 (Metastasis efficiency suppressor gene 1). Mtes1 reached suggestive linkage in the (NZB/BINJ x FVB/N-TgN(MMTVPyVT)634Mul)F1 x FVB/NJ backcross (LOD = 2.3) but not in the other 2 backcrosses. AKR/J-derived alleles appear to confer metastasic suppression at Mtes1. A possible candidate gene for Mtes1 is Brms1.