Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:73583 Sommardahl C, et al., Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype. Physiol Genomics. 2001 Dec 21;7(2):127-34
• ID
  MGI:2179238

Genes

Gene	Assay Type
Ckds	resistance/susceptibility
D4Mit221
D4Mit233

Notes

• Experiment
  The oprk mutation (caused by the insertion of transgene TgN737Rpw) on a FVB/N background results in polycystic kidney disease. The same mutation on a C3HeB/FeJLe background results in a less severe polycystic disease phenotype, longer life span, and development of renal cysts at a slower rate compared to the transgenic FVB/N line. Genome scan was performed on a (C3HeB/FeJLe x FVB/N-TgN737Rpw)F1 x FVB/N-TgN737Rpw backcross and (C3HeB/FeJLe x FVB/N-TgN737Rpw)F2 intercross to identify loci modifying polycystic kidney disease severity. A locus on distal chromosome 4 spanning 58 cM - 75 cM was significantly linked to cystic kidney disease severity and was named Ckds. This locus reached LOD = 2.34 in the backcross and LOD = 2.1 in the F2 intercross. FVB/N-derivedalleles confer increased disease severity in a recessive fashion at Ckds.