Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  18
• Reference
  J:73854 Silverman KA, et al., Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Genome Res. 2002 Jan;12(1):88-97
• ID
  MGI:2181195

Genes

Gene	Assay Type
Atp5f1a	resistance/susceptibility
Apc	reported elsewhere
D18Mit186	PCR amplified length variant
D18Mit213	PCR amplified length variant
D18Mit144	PCR amplified length variant

Notes

• Experiment
  In a mapping study using C57BL/6J x (DBA/2J x C57BL/6J-Apc^Min)F1 and DBA/2J x (DBA/2J x C57BL/6J-Apc^Min)F1 backcross animals, Mom2 was localized to a 10-14 cM region of mouse Chromosome 18 at approximately 50 cM between markers D18Mit186 and D18Mit213. The position of Mom2 is 24.6 cM +/- 3.8 cM distal to Apc. C57BL/6J-derived alleles confer dominantly-inherited protection against polyp formation (88%-95% reduction of polyps) in backcross animals, and this resistance allele was shown to be linked to the Apc^Min mutation in the cis configuration. The tumor resistant effect of Mom2 is stronger than that of Mom1 (Pla2g2-^Mom1-R) on mouse Chromosome 4.