Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  3
• Reference
  J:72606 Suzuki T, et al., The gene mutated in cocoa mice, carrying a defect of organelle biogenesis, is a homologue of the human hermansky-pudlak syndrome-3 gene. Genomics. 2001 Nov;78(1/2):30-7
• ID
  MGI:2181577

Genes

Gene	Assay Type
D3Mit165	overlapping clones, sequence analysis
D3Mit236	overlapping clones, sequence analysis
Hps3	overlapping clones, sequence analysis
Cp	overlapping clones, sequence analysis
Hltf	overlapping clones, sequence analysis
Gyg1	overlapping clones, sequence analysis
Cpa3	overlapping clones, sequence analysis
Cpb1	overlapping clones, sequence analysis

Notes

• Experiment
  Authors used information from the genetic map of the coa interval to construct a BAC map of the region spanning the interval. Exon trapping followed by sequence analysis identified the presence of the Hps3, Cp, Smarca3, Gyg1, Cpa3 and Cpb1 genes in this region. The order of markers on mouse chromosome 3 was determined to be: D3Mit165, D3Mit236 - Cp - Hps3 - Smarca3 - Gyg1 - Cpa3 - Cpb1. The coa phenotype was then found to be caused by mutations in the Hps3 gene with mutations identified in different coa alleles.