Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• ID
  MGI:2182442

Genes

Gene	Assay Type
Bbaa16	resistance/susceptibility
D7Mit227
D7Mit40

Notes

• Experiment
  Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.
  
  A novel QTL, Bbaa16, was identified in the (C57BL/6N X C3H/HeN)F1 X C3H/HeN backcross on Chr 7. Bbaa16 was linked to total IgG levels after infection with B.burgdorferi. It mapped from 16.0 - 53.0 cM between markers D7Mit227 and D7Mit40, LRT=20.1 accounting for 6.8% variance. [Table 2.]
  
  C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.