Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  14
• Reference
  J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• ID
  MGI:2182446

Genes

Gene	Assay Type
Bbaa21	resistance/susceptibility
D14Mit155

Notes

• Experiment
  Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.
  
  A novel QTL, Bbaa21, was identified in the (C57BL/6N X C3H/HeN)F1 X C57BL/6N backcross on Chr 14. Bbaa21 was linked to the number of B.burgdorferi in heart tissue post-infection. It mapped to 25.0 cM with marker D14Mit155, LRT=13.2 accounting for 9.8% variance.
  [Table 2.]
  
  C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.