Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:66636 Nose M, et al., Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. Int J Cardiol. 2000 Aug 31;75 Suppl 1:S53-61; discussion S63
• ID
  MGI:2384714

Genes

Gene	Assay Type
Sials	resistance/susceptibility
D4Mit255

Notes

• Experiment
  Linkage analysis using 139 markers at a density of 10 cM was performed on an MRL/MpJ-Tnfrsf6^lpr/Tnfrsf6^lpr x (C3H/HeJ-Tnfrsf6^lpr/Tnfrsf6^lpr x MRL/MpJ-Tnfrsf6^lpr/Tnfrsf6^lpr)F1 backcross population to map loci associated with 4 types of lesions involved in collagen disease: vasculitis, glomerulonephritis, arthritis, and sialoadenitis. Parental strain MRL/MpJ-Tnfrsf6^lpr/Tnfrsf6^lpr is susceptible to collagen disease whereas parental strain C3H/HeJ-Tnfrsf6^lpr/Tnfrsf6^lpr is resistant. A locus significantly linked to sialoadenitis susceptibility, Sials, in females mapped to mouse Chromosome 4 at approximately 48.5 cM (P<0.0001 at D4Mit255). The MRL/MpJ-derived allele confers recessively inherited susceptibility to sialoadenitis in female animals at this locus. Suggestive loci were also detected for susceptibility to vasculitis (P<0.0009 at D4Mit125), glomerulonephritis (P<0.0007 at D6Mit8), arthritis in males (P<0.0009 at D15Mit183), and sialoadenitis (P<0.0009 at D10Mit20 and D10Mit259).