Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  15
• Reference
  J:70963 Seltzer Z, et al., Mapping a gene for neuropathic pain-related behavior following peripheral neurectomy in the mouse. Pain. 2001 Aug;93(2):101-6
• ID
  MGI:2384722

Genes

Gene	Assay Type
Pain1	visible phenotype
D15Mit28	reported elsewhere
Pvalb	reported elsewhere
Tspo	reported elsewhere
Galr3	reported elsewhere
Il2rb	reported elsewhere
Cacng2	reported elsewhere
Kcnj4	reported elsewhere
Jrk	reported elsewhere

Notes

• Experiment
  395 markers were screened in 23 A/J x C57BL/6J (AXB) and C57BL/6J x A/J (BXA) recombinant inbred (RI) strains to identify loci associated with autonomy. Autonomy is defined as the abnormal behavior of an anesthetic limb including licking, scratching and self-injury. Denervation of the hind limb was accomplished by surgery of the sciatic and saphenous nerves. Animals were evaluated beginning 7 days after surgery. Parental strain A/J displays a high level of autonomy compared to parental strain C57BL/6J. A QTL significantly linked to autonomy, Pain1, mapped from approximately 39 cM - 44 cM on mouse Chromosome 15 with peak linkage at D15Mit28 (P=0.00002) at 43.7 cM. Pain1 maps close to Emo2, a QTL assiciated with fear, anxiety, and depression at 43.3 cM. Potential candidate genes for Pain1 include Pvalb, Bzrp, Galr3, Il2rb, Cacng2, Kcnj4, and Jrk.