Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  5
• Reference
  J:78083 Jung YT, et al., Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice. J Virol. 2002 Aug;76(16):8218-24
• ID
  MGI:2385354

Genes

Gene	Assay Type
D5Mit1
Rmcf	resistance/susceptibility
D5Mit3

Notes

• Experiment
  The authors examined resistance to the mink cell focus-forming (MCF) virus in crosses between the MCF-resistant DBA/2 mice and M. castaneus, a species that lacks endogenous MCF env sequences. Southern blot analysis in backcross progeny showed that resistance and the Rmcf-linked marker D5Mit1 correlated with the inheritance of a specific endogenous MCF virus env-containing 4.6 kb EcoRI fragment. This fragment was present in the DBA/2N substrain with MCF resistance but was absent in the virus-susceptible DBA/2J substrain. The fragment contains a provirus with a 5' LTR and the 5' half of env; the gag and pol genes were partially deleted.