Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:75549 Ohno T, et al., Chromosomal mapping of host susceptibility loci to Angiostrongylus costaricensis nematode infection in mice. Immunogenetics. 2002 Feb;53(10-11):925-9
• ID
  MGI:2385460

Genes

Gene	Assay Type
Acsns1	resistance/susceptibility
D19Mit91
D19Mit3
D19Mit70
D19Mit34
Csf2ra	reported elsewhere

Notes

• Experiment
  A whole genome scan using 95 markers at an average spacing of 20 cM was performed on 207 male (A/J x SM/J)F2 animals to identify loci associated with resistance/susceptibility to infection with the nematode Angiostrongylus costaricensis. Parental strain A/J shows a high survival rate (90.5%) 5 weeks post-infection whereas parental strain SM/J shows a low survival rate (33.3%). Infected SM/J animals exhibit severe anemia and reduced body weight. A locus named Acsns1, Angiostongylus costaricensis nematode susceptibility 1, mapped to distal mouse Chromosome 19 from 47 cM (D19Mit91) to 53 cM (D19Mit34) with a LOD=4.3. Homozygosity for A/J-derived alleles appears to increase survival in infected F2 animals. A potential candidate gene is Csf2ra at 51 cM on mouse Chromosome 19. Epistatic interacting loci were detected at D13Mit248 and D17Mit21. The Chromosome 13 locus is named Acsns2 and the Chromosome 17 locus is named Acsns3. Homozygosity for SM/J-derived alleles at both Acsns2 and Acsns3 confers decreased host survival (P<0.001).