Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:76508 Li X, et al., Genetic Dissection of Femur Breaking Strength in a Large Population (MRL/MpJxSJL/J) of F2 Mice: Single QTL Effects, Epistasis, and Pleiotropy. Genomics. 2002 May;79(5):734-40
• ID
  MGI:2386589

Genes

Gene	Assay Type
Fembrs4	visible phenotype
D17Mit175
Map3k4	reported elsewhere

Notes

• Experiment
  119 polymorphic markers were screened in 633 (MRL/MpJ x SJL/J)F2 female animals to detect loci associated with femur bone mineral density. 7-week old female animals were used for the study. Fembrs4 was identified on mouse Chromosome 17 with LOD=6 at D17Mit175. Fembrs4 also shows significant linkage to femur breaking strength (LOD=8.3) and other traits, such as body weight and femur length, suggesting pleiotropic effects. MRL/MpJ-derived alleles confer increased bone strength with recessive inheritance atFembrs4. A possible candidate gene for Fembrs4 is Map3k4.