Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:76126 Workman MS, et al., Analysis of quantitative trait locus effects on the size and shape of mandibular molars in mice. Genetics. 2002 Apr;160(4):1573-86
• ID
  MGI:2386712

Genes

Gene	Assay Type
Tcsz1	visible phenotype
D7Mit21
Tcsz2	visible phenotype
D7Mit17
Tshp7	visible phenotype
D7Nds1
Tshp8	visible phenotype
D7Mit19

Notes

• Experiment
  76 polymorphic microsatellite markers at an average distance of 27.5 cM were screened in 535 (SM/J x LG/J)F2 animals to identify QTLs associated with tooth development. Parental inbred strain LG/J exhibits larger body size compared to SM/J. QTLs affecting tooth central size (Tcsz1, Tcsz2) and tooth shape (Tshp7, Tshp8) were mapped to mouse Chromosome 7. The Tcsz1 interval spans 0.5 cM - 37 cM and the Tcsz2 interval spans 54 cM - 60 cM on chromosome 7. Both tooth size QTLs exceed the P<0.001 significance threshold of LOD=4.004. Tcsz1 and Tcsz2 exhibit additive inheritance where LG-J-derived alleles contribute to increased tooth size. The QTL intervals of Tshp7 and Tshp8 span 37 cM - 51.41 cM and 44 cM - 51.41 cM, respectively. Both Tshp7 and Tsph8 exceed the P<0.001 significance threshold of LOD=4.185.