Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  14
• Reference
  J:76126 Workman MS, et al., Analysis of quantitative trait locus effects on the size and shape of mandibular molars in mice. Genetics. 2002 Apr;160(4):1573-86
• ID
  MGI:2386713

Genes

Gene	Assay Type
Tcsz3	visible phenotype
D14Mit5

Notes

• Experiment
  76 polymorphic microsatellite markers at an average distance of 27.5 cM were screened in 535 (SM/J x LG/J)F2 animals to identify QTLs associated with tooth development. Parental inbred strain LG/J exhibits larger body size compared to SM/J. A QTL affecting tooth size, Tcsz3, mapped to mouse Chromosome 14 from 22.5 cM - 44.5 cM. Tcsz3 exceeds the P<0.001 significance threshold of LOD=4.004. LG/J-derived alleles confer increased tooth size in an additive fashion at Tcsz3.