Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  15
• Reference
  J:76707 Pitman WA, et al., Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice. Physiol Genomics. 2002;9(2):93-102
• ID
  MGI:2387156

Genes

Gene	Assay Type
Hdlq4	visible phenotype
D15Mit39
Ppara	reported elsewhere

Notes

• Experiment
  90 female animals from an (SM/J x NZB/BlNJ)F1 x NZB/BlNJ backcross population were screened for an initial set of 78 SSLP markers to identify QTLs associated with HDL cholesterol (HDL-C) concentrations. Parental strain NZB/BlNJ exhibits elevated HDL-C onboth a CHOW and atherogenic diet compared to parental SM/J and F1 hybrid animals. A QTL linked to inducible HDL-C on an atherogenic diet, Hdlq4, mapped to 56 cM on mouse Chromosome 15 near D15Mit39 (LOD=2.5). Heterozygous animals exhibit increased induction of HDL cholesterol concentrations at Hdlq4. A possible candidage gene for this locus is Ppara. Suggestive loci were also detected near D6Mit44 (48 cM) and D18Mit24 (18 cM) in linkage to inducible HDL-C, and on mouse Chromosome 11 at 14 cM and 44 cM inlinkage to non-HDL-C on a CHOW diet and non-HDL-C on an atherogenic diet, respectively.