Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:75894 Milhaud JM, et al., Two QTLs located on chromosomes 1 and 5 modulate different aspects of the performance of mice of the B x D Ty RI strain series in the Morris navigation task. Behav Genet. 2002 Jan;32(1):69-78
• ID
  MGI:2387320

Genes

Gene	Assay Type
Sbnt1	visible phenotype
D5Byu4
Spp1

Notes

• Experiment
  26 C57BL/6J x DBA/2J (BXD) recombinant inbred (RI) strains were analyzed for loci linked to spatial abilities during the Morris navigation task. 118 polymorphic markers at an average spacing of 25 cM were screened in 6 animals of each RI strain. A locus with significant linkage to escape latencies during the Morris navigation task, Elnt, mapped to mouse Chromosome 1 with a maximun LOD = 6.23 between 90 cM (D1Mit106) - 98 cM (D1Mit155). A locus linked to spacial bias during the Morris navigation task, Sbnt1, mapped to mouse Chromosome 5 with a LOD peak of 3.72 at 61 cM between Spp1 (56 cM) and D5Byu4 (68 cM). Two other loci affecting spacial bias were shown to interact with Sbnt1, one of which reached statistcal significance on mouse Chromosome 13 with LOD = 3.41 between 23 cM (D13Byu1) - 35 cM (D13Mit13) and was named Sbnt2. The other locus reached suggestive significance on mouse Chromosome 2 with LOD = 2.9 at 49 cM between D2Mc2 (48 cM) and D2Byu3 (69 cM).