Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:76704 Grisel JE, et al., Mapping of Quantitative Trait Loci Underlying Ethanol Metabolism in BXD Recombinant Inbred Mouse Strains. Alcohol Clin Exp Res. 2002 May;26(5):610-6
• ID
  MGI:2387323

Genes

Gene	Assay Type
Etmr	visible phenotype
D17Leh507
Ly39	reported elsewhere
Cryaa	reported elsewhere
Sod2	reported elsewhere

Notes

• Experiment
  25 BXD (C57BL/6J x DBA/2J) recombinant inbred (RI) strains were screened for loci associated with blood ethanol concentration (BEC) and ethanol metabolism after IP ethanol administration. Parental strain C57BL/6J exhibits 10-15% slower elimination of blood alcohol compared to parental strain DBA/2J.
  
  A locus mapping to 6.27 cM on mouse Chromosome 17, Etmr, reached statistical significance (P<0.001) in linkage with ethanol metabolism rate. Etmr has a QTL range of 3 cM - 20 cM on chromosome 17. A possiblecandidate gene for Etmr is Sod2.