Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• ID
  MGI:2387383

Genes

Gene	Assay Type
Sluc15	resistance/susceptibility
D1Mit170

Notes

• Experiment
  Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.
  
  In the (OcB3 x O20/A)F2 cross a newly identified QTL, Sluc15, was mapped to mouse Chromosome 1 in linkage to D1Mit170 at approximately 19.5 cM.