Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• ID
  MGI:2387385

Genes

Gene	Assay Type
Sluc18	resistance/susceptibility
D4Mit4
Sluc21	resistance/susceptibility
D4Mit70

Notes

• Experiment
  Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.
  
  In the (OcB4 x O20/A)F2 cross newly identified QTL Sluc18 mapped to mouse Chr 4 in linkage with D4Mit4 at approximately 12.1 cM.
  
  In the (OcB16 x O20/A)F2 cross newly identified QTL Sluc21 mapped to mouse Chr 4 in linkage with D4Mit70 at approximately 62.3 cM.