Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  15
• Reference
  J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• ID
  MGI:2387392

Genes

Gene	Assay Type
Sluc24	resistance/susceptibility
D15Mit13
Sluc25	resistance/susceptibility
D15Nds3
Sluc26	resistance/susceptibility
D15Mit96

Notes

• Experiment
  Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.
  
  In the (OcB16 x O20/A)F2 cross a newly identified QTL, Sluc24, mapped to Chr 15 in linkage with D15Mit13 at approximately 6.7 cM.
  
  In the (OcB4 x O20/A)F2 cross newly identified QTL, Sluc25, mapped to Chr 15 in linkage with D15Nds3 at approximately 32.0cM. In the same cross, Sluc26, mapped to mouse Chr 15 in linkage with D15Mit96 at approximately 48.9 cM.