Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  5
• Reference
  J:78974 Mashimo T, et al., A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11311-6
• ID
  MGI:2388362

Genes

Gene
D5Mit431
D5Mit368
D5Mit426
D5Mit321
D5Mit159
Oas1a
Oas1b

Notes

• Experiment
  Strains BALB/c and C57BL/6 were susceptible to West Nile virus (Wnv) whereas MAI/Pas and MBT/Pas were resistant. The Authors used the aformentioned strains in 4 backcrosses to show the Wnv phenotype to segregate within a region of mouse Chromosome 5 flanked by D5Mit431 and D5Mit321. Further crossing refined this region to .46 cM to include D5Mit159 and D5Mit368. Radiation Hybrid maps and sequence analysis were informative to indentify canditate genes within the region, A C-T transiston in exon fourof Oas1a results in the occurrence of a stop codon in susceptible mice.