Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:78920 Plum L, et al., L. Plum et al.: The mouse diabetes susceptibility locus Nidd/SJL. Diabetologia. 2002 Jun;45(6):823-30
• ID
  MGI:2388836

Genes

Gene	Assay Type
Nidds	resistance/susceptibility
D4Mit278
D4Mit203
Lepr	resistance/susceptibility
Slc2a1	resistance/susceptibility
Bmp8a	resistance/susceptibility
Ptafr	resistance/susceptibility
Cdc42	resistance/susceptibility

Notes

• Experiment
  Linkage analysis was performed on 199 male NZO/HlBom x (SJL/NBom x NZO/HlBom)F1 backcross animals to identify QTLs associated with susceptibility to diabetes. Parental strain NZO is obese and susceptible to diabetes whereas parental strain SJL is lean and diabetes resistant. A QTL linked to severe hyperglycemia mapped to mouse Chromosome 4 from approximately 40 cM - 70 cM with peak linkage of LOD=9.9 at D4Mit278 (55.2 cM) and D4Mit203 (60 cM). This locus, Nidds (non-insulin-dependent diabetes mellitus inSJL), is also linked to beta cell loss, but not to obesity or early hyperinsulinemia. Heterozygosity for SJL-derived alleles at Nidds confers susceptibility to late onset diabetes in response to either a standard or high fat diet. Homozygosity for NZO/HlBom-derived alleles at Nod1, a previously identified obesity locus on mouse Chromosome 5, interacts with Nidds to accelerate onset of diabetes in response to a high fat diet. Nod1 did not show this effect on a standard diet.