Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:78926 de Haan G, et al., A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover. Blood. 2002 Sep 15;100(6):2056-62
• ID
  MGI:2388986

Genes

Gene	Assay Type
Scpro2	visible phenotype
D11Mit131
D11Mit178
Pafah1b1	reported elsewhere
Tbx2	reported elsewhere

Notes

• Experiment
  Scpro2, a QTL associated with stem cell proliferation rates, was mapped and confirmed in 33 BXD (B=C57BL/6; D=DBA/2) recombinant inbred (RI) strains and 60 C57BL/6 x (C57BL/6 x DBA/2)F1 backcross animals. Scpro2 mapped to D11Mit131 (29 CM) in the BXD RI set and to D11Mit178 (47 cM) in the backcross set. DBA/2-derived alleles are associated with higher cell proliferation rates. Scpro2 was further confirmed in congenic line B6.D2-Scpro2. This congenic carries DBA-derived DNA from 39 cM - 49 cM on Chromosome 11 on a C57BL/6 genetic background. This congenic recapitulates the high cell cycling rates of donor strain DBA/2. Potential candidate genes for Scrpo 2 are Pafah1b1 and Tbx2.