Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:78754 Beamer WG, et al., Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206
• ID
  MGI:2389144

Genes

Gene	Assay Type
Bmd5	visible phenotype
D1Mit14

Notes

• Experiment
  Linkage analysis was performed on 986 (C57BL/6J x C3H/HeJ)F2 female animals using 107 microsatellite markers to identify QTLs associated with bone mineral density (BMD). Parental strain C3H/HeJ exhibits higher bone mineral density values compared to C57BL/6J. Bmd5 mapped to 81.6 cM on mouse Chromosome 1 with a peak LOD=24.44 at D1Mit14 in linkage to femoral and vertebral BMD. The QTL range of Bmd5 spans 52 cM - 106.3 cM. C3H/HeJ-derived alleles confer an additively-inherited increase in femoral and vertebral BMD at Bmd5.