Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  18
• Reference
  J:79322 Wilson SM, et al., Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet. 2002 Nov;32(3):420-5
• ID
  MGI:2429771

Genes

Gene	Assay Type
D18Mit66	PCR
D18Mit65	PCR
D18Mit109	PCR
D18Mit164	PCR
D18Mit64	PCR
Rab18	PCR
D18Mit168	PCR
D18Mit166	PCR
D18Fcr14	PCR
D18Fcr23	PCR
Usp14
D18Mit192	PCR
D18Mit110	PCR
D18Mit67	PCR
D18Fcr13	PCR
Lama3	PCR
D18Mit146	PCR
D18Mit30	PCR

Notes

• Experiment
  The following cross was used to map loci on mouse Chromosome 18:(C57BL/6J-ax^J ax^J CAST/Ei)F1 (C57BL/6Jax^Jax^J CAST/Ei)F1. 757 F2 mice were informative to define the critical region containing the ataxia phenotype. Further the authors determined that ataxia is a mutation in Usp14. The following order was determined: D18Mit66 - 0.6 +/- 0.32 cM - D18Mit65 - D18Mit109 - 0.1 +/- 0.12 cM - D18Mit164 - D18Mit64 - Rab18 - 0.1 +/- 0.12 cM - D18Mit168 - D18Mit166 - 0,4 +/- 0.42 cM - D18Fcr14 - 0.1 +/- 0.12 cM - D18Fcr23 - Usp14 - 0.1 +/- 0.12 cM - D18Mit192 - D18Mit110 - D18Mit67 - D18Fcr13 - 0.1 +/- 0.12 cM - Lama3 - D18Mit146 - 0.1 +/- 0.12 cM - D18Mit30.